Table 1 Conserved regions in HCV NS3/4A, NS5A and NS5B.

From: Exploring NS3/4A, NS5A and NS5B proteins to design conserved subunit multi-epitope vaccine against HCV utilizing immunoinformatics approaches

Conserved regions (NS3/4A)

Positions

APITAY

1–6

LLSPRP

126–131

FRAAVC

154–159

LHAPTGSGKSTKVP

202–215

VLVLNPSVAATLGFG

225–239

TYSTYGKFLADGGC

266–279

IICDECH

287–293

LGIGTVLDQAETAG

301–314

VLATATPPGS

319–328

GEIPFYG

345–351

KGGRHLIFCHSKKKCDE

360–376

TDALMTG

411–417

TGDFDSVIDCN

419–429

VDFSLDPTF

436–444

PQDAVSR

452–458

QRRGRTGRG

460–468

TPGLPVCQDHL

519–529

VFTGLT

535–540

LSQTKQ

547–552

AYQATVC

562–568

APPPSWD

572–579

GPTPLLYRLG

594–603

TSTWVL

631–636

Conserved Regions NS5/A

Positions

GTFPIN

86–91

GSQLPC

185–190

RGSPPS

220–225

ASSSASQLSAPSL

227–239

SSMPPLEGEPGDP

421–433

Conserved Regions NS5B

Positions

KKVTFDR

50–56

TTIMAKNEVF

136–145

PDLGVRVCEK

163–172

YGFQYSP

191–197

YDTRCFDSTVTE

219–230

CGYRRCRASGV

274–284

LVCGDDLV

314–321

FTEAMTRYSAPPGD

339–352

TSCSSNVSVA

364–373

YYLTRD

382–387

ARAAWET

393–399

PVNSWLGNII

404–413

MTHFFS

426–431

YLFNWAV

524–530

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