Table 6 Characterization of deleterious SNPs identified in eight PCGs.
Associated Gene Name | SNP ID | GGA | Genome positiona | SIFT scoreb | Amino acid changed |
|---|---|---|---|---|---|
FOXO1 | g.170581941 > C/T | 1 | 170,581,941 | deleterious low confidencec (0.01) | Pro/Leu |
NR4A2 | g.36224286 > C/T | 7 | 36,224,286 | deleterious (0) | Val/Met |
g.36225242 > G/T | 36,225,242 | deleterious (0) | Arg/Ser | ||
g.36225278 > C/T | 36,225,278 | deleterious (0.01) | Val/Met | ||
SIRT4 | rs316192467 | 15 | 9,435,175 | deleterious (0.02) | Ala/Thr |
DOK5 | g.12473540 > C/A | 20 | 12,473,540 | deleterious (0.02) | Lys/Asn |
ANGPTL4 | g.846035 > G/A | 28 | 846,035 | deleterious (0.03) | Ser/Phe |
TM6SF2 | g.3553753 > T/C | 28 | 3,553,753 | deleterious low confidencec (0.01) | Leu/Pro |
rs315426765 | 3,554,427 | deleterious (0.05) | Leu/Phe | ||
rs741325985 | 3,554,836 | deleterious (0.04) | Val/Met | ||
SLC39A3 | rs316529053 | 28 | 3,285,533 | deleterious (0) | Arg/His |
SLC35E1 | g.4327417 > G/A | 28 | 4,327,417 | deleterious (0.05) | Gly/Arg |
