Figure 2
From: NF-κB p65 directs sex-specific neuroprotection in human neurons
ITSCs differentiate into glutamatergic neurons after transplantation into ex vivo-cultivated murine organotypic hippocampal slices. (a) Schematic view showing experimental design of ITSC-transplantation into organotypic hippocampal slices. (b) Immunocytochemistry showing differentiation of ITSCs into MAP-2 and Gat-1 positive neurons, indicating successful integration of transplanted ITSCs into organotypic hippocampal slices. (d) Schematic view showing the transplantation procedure of GFP-positive ITSCs into organotypic hippocampal slices. E: GFP+-ITSCs integrated within the dentate gyrus of the hippocampus and exhibited a neuronal phenotype accompanied by expression of vGlut2 and Synaptophysin.
