Figure 6
From: Acid bone lysate activates TGFβ signalling in human oral fibroblasts
Acid bone lysate (ABL) activates TGF-β-Smad2/3 signaling in primary oral fibroblasts. Incubation of gingival fibroblasts with ABL also caused an increased phosphorylation of Smad3 (a). Representative immunofluorescence confirmed the translocation of Smad2/3 into the nucleus upon stimulation with ABL (b). Treatment with 10 ng/ml of TGF-β was used as a positive control.
