Figure 1
From: Characterization of a recurrent missense mutation in the forkhead DNA-binding domain of FOXP1
FOXP1 p.R525 mutations map to the FOX DNA-binding domain. FOXP1 protein structure is composed of common conserved domains: an N-terminal Q-rich (polyglutamine) domain, internal zinc-finger (ZF) and leucine zipper (LZ), and a C-terminal forkhead box DNA-binding domain (FOX). Additionally, two nuclear localization signals (NLS) are present at the C-terminus that target the protein to the nucleus under normal conditions. Arginine 525 is localized to the DNA-binding FOX domain nestled between the two NLS.
