Figure 3
From: Characterization of a recurrent missense mutation in the forkhead DNA-binding domain of FOXP1
Localization of the FOXP1 proteins in HeLa cells. Expression constructs containing WT FOXP1, truncating p.R525* mutant, and p.R525Q missense mutant were transiently transfected into HeLa cells. WT and p.R525Q mutant properly localize to the nucleus in identical patterns while the p.R525* truncation results in cytoplasmic aggregation.
