Table 1 SNPs associated with plasma levels of MCP1, VEGF-C, and VEGF-A in CALGB 80303.

From: Genetic variation determines VEGF-A plasma levels in cancer patients

Protein

SNP

Gene

5′ flanking

3′ flanking

Base

MAF

Median protein levels (pg/ml) for 0, 1, or 2 minor alleles

P-value

MCP1

rs2284284

NRCAM

NRCAM

PNPLA8

A > G

0.292

592.9, 476.0, 395.0

6.7e–08

0.286

863.8, 936.3, 917.5

0.481

VEGF-C

rs7504372

—

TMEM200C

L3MBTL4

T > C

0.086

494.1, 1350.0, 291.4

9.8e–09

0.096

1286.7, 1577.0, NA

0.314

VEGF-A

rs7767396

—

LOC100132354

C6orf223

A > G

0.470

195.3, 95.7, 58.1

5.8e–09

0.522

529.5, 230.4, 199.4

5.2e–05

  1. “MAF” stands for minor allele frequency. For MAF, median levels, and P-values, the top values are from CALGB 80303 (discovery cohort) and the bottom values are from CALGB 80203 (validation cohort). P-values for Hardy-Weinberg Equilibrium in the discovery cohort are 0.25, 0.50, and 1.00 for rs2284284, rs7767396, and rs7504372, respectively. In the validation cohort, the P-values were 0.04, 0.19, and 0.60 respectively. Due to limitations in DNA quantity or quality, genotypes for rs7767396 and rs7504372 could not be determined for two and three patients, respectively, in CALGB 80203.
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