Table 3 Functional classification and tested proteins according to data of NanoLC-MS/MS analysis following BTZ and CFZ treatments.
From: Proteomic approach for understanding milder neurotoxicity of Carfilzomib against Bortezomib
Classification | Tested Proteins | Time Point | Result (BTZ vs CONT) | Result (CFZ vs CONT) |
|---|---|---|---|---|
Cytoskeletal proteins | Nestin | 24 h | Decreased | Decreased |
Vimentin | 24 h | Increased | Decreased | |
Actin Related Protein-2 | 3 h | Increased | Increased | |
Transgelin-2 | 3 h | Not changed | Not changed | |
Coronin 1 C | 3 h | Not changed | Not changed | |
β-actin | 3 h | Decreased | Decreased | |
β-tubulin | 24 h | Increased | Increased | |
Chaperone System | HSP32 | 24 h | Increased | Not changed |
HSP47 | 24 h | Increased | Not changed | |
HSP70 | 24 h | Increased | Not changed | |
GRP78 | 24 h | Increased | Increased | |
GRP94 | 24 h | Increased | Increased | |
Protein Oxidation | Ubiquitinated proteins | 24 h | Increased | Increased |
Carbonylated proteins | 24 h | Increased | Increased |
