Figure 8 | Scientific Reports

Figure 8

From: Receptor-Ligand Interaction Mediates Targeting of Endothelial Colony Forming Cell-derived Exosomes to the Kidney after Ischemic Injury

Figure 8

Effect of exosomal CXCR4 on kidney ischemic injury. Graphs depict data obtained 24 hrs after reperfusion in mice subjected to ischemic kidney injury (IR), with or without i.v. administration of endothelial colony forming cell exosomes (IR+EX), or exosomes pre-incubated with the CXCR4 antagonist plerixafor (IR+EX+Plerixafor). (a) Plasma Cr and Blood Urea Nitrogen (BUN) levels 24 hrs after reperfusion. *P < 0.05 vs IR+EX. (b) Kidney histologic injury scores for mice with kidney ischemia, 24 hrs after reperfusion, with or without exosomes. *P < 0.001 vs IR+EX; Representative photomicrographs are shown above graph. Astericks (*) depict tubular cast formation, arrows depict hallmark tubular dilatation, and arrowheads depict nuclear loss. (c) Quantitative assessment of neutrophil infiltration in kidneys (number of neutrophils per field), for mice with kidney ischemia, 24 hrs after reperfusion, with or without exosomes. *P < 0.001 vs IR+EX. Representative photomicrographs are shown above graph. Arrows depict peritubular neutrophil infiltrate. Data are from 4 mice in each group, except for IR alone, (n = 6 mice).

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