Figure 1
Expression of prostaglandin E2 synthesizing enzymes, IL-1β and TNF-α in liver samples of control, steatosis and NASH patients as well as correlation with NASH activity score (NAS). Relative mRNA expression of COX-2 (gene name PTGS2) (A,B), mPGES-1 (gene name PTGES) (C,D), tumor necrosis factor α (TNF-α) (E,F) and interleukin-1β (IL-1β) (G,H) were determined in liver samples of a cohort described previously24,25. Patient characteristics were summarized in Supplementary Table 1. Values are median (line), upper- and lower quartile (box) and extremes (whiskers) of 27–34 controls, 27–46 patients with hepatosteatosis and 27–43 patients with NASH (A–G). Single values of COX-2 and mPGES-1 expression were correlated with NAS of controls (NAS < 1), patients with steatosis (1 < NAS ≤ 5) and patients with NASH (NAS > 5) (B,D) and single values of and IL-1β and TNF-α expression were correlated with NAS of patients with steatosis (1 < NAS ≤ 5) and patients with NASH (NAS > 5) (F, H). Statistics: (A–G) One-way-ANOVA with Tukey’s post hoc test for multiple comparisons, *p < 0.05; (B–H) Spearman correlation.
