Table 1 NASH activity score grading steatosis, ballooning (hepatocyte hypertrophy), inflammation and fibrosis in wild-type and mPGES-1-deficient mice.

From: Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model

Scoring parameter

Standard-diet mPGES-1+/+ [WT]

Standard-diet mPGES-1−/− [KO]

NASH-diet mPGES-1+/+ [WT]

NASH-diet mPGES-1−/− [KO]

Steatosis

0.00 ± 0.00

0.00 ± 0.00

3.88 ± 0.07

3.47 ± 0.26

Hepatocyte hypertrophy

0.00 ± 0.00

0.00 ± 0.00

1.67 ± 0.12

1.47 ± 0.18

Inflammation

0.05 ± 0.05

0.20 ± 0.11

1.58 ± 0.16

1.89 ± 0.20

Fibrosis

0.30 ± 0.11

0.13 ± 0.09

0.96 ± 0.04

1.00 ± 0.00

NASH activity score (NAS)

0.00 ± 0.00

0.00 ± 0.00

8.08 ± 0.21*

7.84 ± 0.44#

  1. Values are mean ± SEM of 15–25 mice per group. Statistics: Mann-Whitney-U-Test. *p < 0.05.
  2. *versus STD WT.
  3. #versus STD KO.
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