Figure 5

In horses with asthma, gene sets for leukocyte chemotaxis and migration were significantly enriched. The y-axis represents enrichment score (ES) and on the x-axis are genes (vertical black lines) represented in gene sets. The green line connects points of ES and genes. ES is the maximum deviation from zero as calculated for each gene going down the ranked list, and represents the degree of over-representation of a gene set at the top or the bottom of the ranked gene list. The colored band at the bottom represents the degree of correlation of genes with the asthma phenotype (red for positive and blue for negative correlation). Significance threshold set at FDR < 0.05. Gene sets for leukocytes were significant only in horses with asthma.