Table 4 Top up-regulated gene-sets in non-asthmatic horses following challenge, ranked according to FDR.

From: Gene set enrichment analysis of the bronchial epithelium implicates contribution of cell cycle and tissue repair processes in equine asthma

Name of gene set

Size of gene set

NES^

FDR*

Rank at max

Translation - reactome - react_1014.4

118

2.20

<0.001a

1771

Cap-dependent translation initiation - reactome - react_2099.1

88

2.16

<0.001a

1771

3′ -utr-mediated translational regulation - reactome - react_1762.2

80

2.15

<0.001a

1503

M phase - reactome - react_910.4

213

2.15

<0.001a

1647

l13a-mediated translational silencing of ceruloplasmin expression - reactome - react_79.2

80

2.15

<0.001a

1503

Eukaryotic translation initiation - reactome - react_2159.5

88

2.14

<0.001a

1771

Protein targeting to er - gobp - go:0045047

87

2.14

<0.001a

1869

Mitotic prometaphase - reactome - react_682.3

96

2.13

<0.001a

1249

Gtp hydrolysis and joining of the 60 s ribosomal subunit - reactome - react_2085.2

81

2.13

<0.001a

1771

Cotranslational protein targeting to membrane - gobp - go:0006613

85

2.11

<0.001a

1869

  1. ^Normalized enrichment score.
  2. *False discovery rate.
  3. aExact FDR value not detected (<1/maximum number of permutations).
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