Table 5 Most enriched transcription factor motifs among significantly up- and down-regulated genes in horses with asthma following challenge.
Transcription factor motif ID | NES^ | Transcription factors |
|---|---|---|
Up-regulated genes | ||
Transfac_pro-M00920 | 8.72 | E2F7, TFDP1, E2F3*, E2F4, E2F1, TFDP3, E2F5, E2F2* |
Transfac_pro-M00919 | 8.72 | E2F1, TFDP1, E2F3*, E2F4, TFDP3, E2F7, E2F2*, E2F5 |
Swissregulon-E2F1.5.p2 | 8.63 | E2F2*, E2F4, E2F1, E2F5, E2F3*, TFDP1, E2F7, TFDP3 |
Homer-M00032 | 8.56 | E2F7, E2F4, E2F6, E2F1 |
Transfac_pro-M00740 | 8.30 | E2F1, E2F3*, E2F4, E2F5, E2F2*, TFDP1, E2F7, TFDP3 |
Transfac_pro-M00738 | 8.29 | E2F4, E2F1, E2F5, E2F3*, E2F2*, TFDP1, E2F7, TFDP3 |
Jaspar-PF0069.1 | 8.25 | E2F4, E2F7, E2F6, E2F1, E2F8* |
Homer-M00028 | 8.18 | E2F1, E2F4, E2F3*, E2F7, TFDP1, E2F5, E2F2*, TFDP3 |
Transfac_pro-M00939 | 8.15 | E2F1, TFDP1, E2F4, E2F3*, TFDP3, E2F7, E2F5, E2F2* |
Transfac_public-M00050 | 8.11 | E2F4, TFDP1, E2F3*, E2F1, TFDP3, E2F7, E2F5, E2F2* |
Down-regulated genes | ||
Transfac_pro-M02790 | 5.24 | RFX7, RFX5# |
Transfac_pro-M02789 | 4.69 | RFX4, RFX5#, RFX7 |
Taipale-SGTTGCYARGCAACS-RFX4-DBD | 4.58 | RFX4, RFX3, RFX2#, RFX1# |
Taipale-SGTTGCYARGCAACS-Rfx2-DBD | 4.57 | RFX3, RFX2#, RFX4, RFX1# |
Taipale-GTAAACAW-FOXO3-full | 4.57 | FOXO3, FOXC2, FOXO1, FOXF2, FOXD1, FOXD2, HLTF, FOXO4#, FOXO6, FOXA1, FOXA2, FOXJ2, FOXI1, FOXK1 |
Swissregulon-FOX_D1-D2_.p2 | 4.47 | FOXD1, FOXD2, FOXO1, HLTF, FOXC2, FOXF2, FOXO3, FOXA2, FOXA1, FOXO6, FOXJ2, FOXO4#, FOXK1 |
Taipale-SGTTGCYARGCAACS-RFX2-DBD | 4.26 | RFX2#, RFX3, RFX4 |
Yetfasco-501 | 4.26 | N/A |
Yetfasco-1452 | 3.80 | HLF, TEF#, NFIL3, DBP#, ATF2 |
Homer-M00165 | 3.80 | RFX5#, RFX1#, RFX7 |
