Table 2 List of genes contributing to different cellular biological processes in PCa.

From: Dysregulated gene expression predicts tumor aggressiveness in African-American prostate cancer patients

Biological component

Gene symbol

Parents Identifier

Regulation of apoptotic process

CD24, CDKN1B, CLU, CNR1, CTNNB1, CYP1B1, EGFR, F3, ALDH1A3, FLNA, ALOX12, GREM1, ANXA1, HIF1A, GADD45B, NKX3-1, PTGS2, SHH, SOD1, SOCS2, ADIPOQ

GO:0042981

Response to steroid hormone

CD24, CDKN1B, CTNNB1, EGFR, F3, FOS, ANXA1, HIF1A, LOX, NKX3-1, PTGS2, SREBF1, SOCS2, ADIPOQ

GO:0048545

Fatty acid biosynthetic process

ALOX12, ANXA1, PTGS2, FASN, LTC4S

 

Lipid metabolic process

CLU, CNR1, COMT, CYP1B1, EGFR, FASN, ALDH1A3, FGF2, ALOX12, ANXA1, IMPA1, LTC4S, PTGS2, SHH, SOD1, SREBF1, ADIPOQ, PTGES

GO:0006629

Response to estradiol

CDKN1B, CTNNB1, EGFR, F3, ANXA1, HIF1A, PTGS2, SOCS2

GO:0032355

Regulation of cell proliferation

CD24, CDKN1B, CLU, COMT, CTNNB1, CYP1B1, EGFR, F3, FGF2, ALOX12, GREM1, ANXA1, HIF1A, NKX3-1, AZGP1, PTGS2, SHH, ADIPOQ, PTGES

GO:0042127

Regulation of cell motility

CYP1B1, EGFR, F3, FGF2, ALOX12, ANXA1, PTGS2, SHH, FLNA, ADIPOQ, HIF1A, MYLK, GREM1

GO:2000145

Positive regulation of cell differentiation

CD24, CDKN1B, CLU, CTNNB1, EGFR, F3, ALOX12, GREM1, ANXA1, HIF1A, NKX3-1, PTGS2, SHH, FGF2

GO:0045597

Regulation of cell migration

CYP1B1, EGFR, F3, FGF2, FLNA, ALOX12, GREM1, ANXA1, HIF1A, MYLK, PTGS2, SHH, ADIPOQ

GO:0030334

Regulation of angiogenesis

CTNNB1, CYP1B1, F3, FGF2, ALOX12, GREM1, HIF1A, PTGS2

GO:0045765

Positive regulation of signal transduction

CD24, CLU, CTNNB1, CYP1B1, EGFR, F3, FGF2, FLNA, GREM1, HIF1A, GADD45B, NKX3-1, PTGS2, SHH, SOD1, SOCS2, ADIPOQ

GO:0009967

Regulation of protein transport

CNR1, EGFR, FLNA, GREM1, ANXA1, HIF1A, OAZ2, PTGS2, SHH, SREBF1, ADIPOQ, CDH1

GO:0051223

Regulation of cell adhesion

CD24, CTNNB1, CYP1B1, FLNA, ALOX12, GREM1, ANXA1, SHH, SOD1, ADIPOQ, CDH1

GO:0030155

Cellular response to reactive oxygen species

CYP1B1, F3, FOS, ANXA1, HIF1A, SOD1

GO:0034614

Enzyme linked receptor protein signaling pathway

CTNNB1, EGFR, F3, FGF2, CYFIP1, FOS, GREM1, HIF1A, NKX3-1, SHH, SREBF1, SOCS2, ADIPOQ

GO:0007167

Transmembrane receptor protein tyrosine kinase signaling pathway

CTNNB1, EGFR, F3, FGF2, CYFIP1, GREM1, HIF1A, NKX3-1, SREBF1, SOCS2, ADIPOQ

GO:0007169

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