Table 1 The comparison of clinic and laboratory characteristic in patients between hepatic significant fibrosis and no/minor fibrosis.

From: Serum Golgi protein 73 is a marker comparable to APRI for diagnosing significant fibrosis in children with liver disease

Variables

Age <3years (n = 116)

Age ≥ 3years (n = 67)

S0-1(n = 31)

S2-4(n = 85)

P-Value

S0-1(n = 26)

S2-4(n = 41)

P-Value

Age (month)

17.1 ± 10.8

10 ± 8.5

P < 0.001 

89.4 ± 51.7

81.9 ± 35.7

P = 0.48

GP73 (ng/ml)

162 ± 78.5

239 ± 82.3

P < 0.001

128.4 ± 81.7

149.6 ± 58.8

P = 0.22

TB (umol/L)

19.1 ± 30.6

142 ± 108

P < 0.001

48 ± 65

43.3 ± 70.8

P = 0.61

ALT (U/L)

207 ± 184

257 ± 296

P = 0.493

203 ± 460

162 ± 182

P = 0.62

AST (U/L)

169 ± 157

355 ± 347

P = 0.002

117.6 ± 136

176.5 ± 192

P = 0.12

ALB (g/L)

43.3 ± 2.3

40.2 ± 4.7

P = 0.001

44.3 ± 3.1

41.7 ± 5.2

P = 0.028

GGT (U/L)

93.8 ± 114

140 ± 179

P = 0.016

209.6 ± 378

109.7 ± 144

P = 0.425

TBA (umol/l)

42 ± 106

180 ± 111

P < 0.001

98.6 ± 164

69.8 ± 111.5

P = 0.62

PLT (10*9/L)

299 ± 146

326 ± 166

P = 0.419 

225.8 ± 95

223 ± 112

P = 0.918

Inflammation

0.94 ± 0.73

2.2 ± 0.88

P < 0.001

1 ± 0.6

1.8 ± 1

P = 0.001

  1. Abbreviation: GP73 = Golgi protein 73, TB = Total bilirubin, ALT = Alanine transaminase, AST = Aspartate transaminase, ALB = Serum albumin, GGT = Gamma glutamyl transpeptidase, TBA = Total bile acid, PLT = Platelet. P values were calculated by student’s t-test and Mann-Whitney U test.
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