Table 1 3D MR imaging-based brain volumetric analysis.
Region | Structure | Sub-structure | Average (mm3) | Change in absolute volume (%) | Groupwise difference uncorrected p value | |
|---|---|---|---|---|---|---|
WT | Brd1 +/− | |||||
Cerebral grey | Cerebral Cortex | Frontal Cortex | 46.0 ± 0.9 | 44.7 ± 0.8 | −2.8 | 0.30 |
Occipital Cortex | 6.5 ± 0.2 | 5.9 ± 0.2 | −9.8 | 0.02 | ||
Parieto-temporal Cortex | 80.3 ± 2.0 | 78.3 ± 2.2 | −2.5 | 0.51 | ||
Entorhinal Cortex | 10.1 ± 0.7 | 9.6 ± 0.6 | −5.2 | 0.55 | ||
143.0 ± 3.3 | 138.5 ± 3.6 | −3.1 | 0.37 | |||
Hippocampus | Hippocampus Proper | 24.0 ± 0.4 | 22.7 ± 0.5 | −5.5 | 0.07 | |
Dentate Gyrus | 4.6 ± 0.3 | 4.1 ± 0.1 | −10.8 | 0.14 | ||
Stratum Granulosum | 1.1 ± 0.0 | 1.0 ± 0.0 | −6.0 | 0.11 | ||
29.7 ± 0.7 | 27.8 ± 0.7 | −6.4 | 0.07 | |||
Amygdala | 16.3 ± 0.2 | 15.5 ± 0.2 | −5.3 | 0.01 | ||
Striatum | Caudate Nucleus/Putamen | 20.5 ± 0.5 | 18.4 ± 0.5 | −10.3 | <0.01 | |
Fundus of Striatum | 0.2 ± 0.0 | 0.2 ± 0.0 | 0.9 | 0.90 | ||
Nucleus Accumbens | 4.4 ± 0.2 | 4.3 ± 0.1 | −3.6 | 0.45 | ||
25.1 ± 0.6 | 22.8 ± 0.5 | −9.1 | 0.01 | |||
Subiculum (pre-para) | 0.3 ± 0.1 | 0.4 ± 0.1 | 28.9 | 0.38 | ||
Globus Pallidus | 3.2 ± 0.1 | 3.0 ± 0.1 | −6.9 | 0.03 | ||
Thalamus | 18.4 ± 0.4 | 17.6 ± 0.5 | −4.1 | 0.27 | ||
Hypothalamus | 12.1 ± 0.3 | 11.6 ± 0.4 | −3.7 | 0.39 | ||
Mammillary Bodies | 0.6 ± 0.0 | 0.6 ± 0.1 | 0.1 | 1.00 | ||
Medial Septum | 1.5 ± 0.1 | 1.4 ± 0.1 | −3.0 | 0.64 | ||
Lateral Septum | 3.9 ± 0.2 | 3.8 ± 0.2 | −2.5 | 0.76 | ||
Basal Forebrain | 5.0 ± 0.1 | 4.9 ± 0.2 | −1.8 | 0.68 | ||
Bed Nucleus of Stria Terminalis | 1.5 ± 0.1 | 1.5 ± 0.1 | 0.2 | 0.98 | ||
260.6 ± 5.7 | 249.5 ± 5.7 | −4.3 | 0.19 | |||
Cerebral white | Anterior Commissure: pars anterior | 1,7 ± 0.1 | 1.5 ± 0.0 | −9.5 | 0.01 | |
Anterior Commissure: pars posterior | 0,5 ± 0.0 | 0.5 ± 0.0 | −1.9 | 0.80 | ||
Posterior Commissure | 0.1 ± 0.0 | 0.1 ± 0.0 | −4.5 | 0.43 | ||
Cerebral Peduncle | 2.6 ± 0.1 | 2.5 ± 0.1 | −4.3 | 0.37 | ||
Corpus Callosum | 17.1 ± 0.4 | 16.5 ± 0.2 | −3.1 | 0.18 | ||
Fasciculus Retroflexus | 0.3 ± 0.0 | 0.3 ± 0.0 | 0.8 | 0.87 | ||
Fimbria | 3.5 ± 0.1 | 3.2 ± 0.1 | −7.4 | 0.12 | ||
Fornix | 0.8 ± 0.1 | 0.7 ± 0.1 | −2.8 | 0.79 | ||
Habenular Commissure | 0.0 ± 0.0 | 0.0 ± 0.0 | −11.0 | 0.38 | ||
Internal Capsule | 3.0 ± 0.1 | 2.8 ± 0.1 | −5.7 | 0.15 | ||
Mammilothalamic Tract | 0.36 ± 0.0 | 0.3 ± 0.0 | −2.1 | 0.74 | ||
Optic Tract | 1.9 ± 0.1 | 1.9 ± 0.1 | −0.4 | 0.94 | ||
Stria Medullaris | 0.8 ± 0.0 | 0.8 ± 0.0 | −2.7 | 0.62 | ||
Stria Terminalis | 1.0 ± 0.0 | 1.0 ± 0.0 | −5.4 | 0.25 | ||
33.4 ± 0.6 | 32.1 ± 0.5 | −4.1 | 0.10 | |||
Olfactory | Olfactory Bulbs | 29.2 ± 0.5 | 29.4 ± 0.7 | 0.5 | 0.88 | |
Olfactory Tubercle | 4.1 ± 0.1 | 3.9 ± 0.1 | −3.4 | 0.45 | ||
Lateral Olfactory Tract | 1.6 ± 0.1 | 1.6 ± 0.1 | −3.3 | 0.48 | ||
34.9 ± 0.6 | 34.9 ± 0.9 | −0.1 | 0.96 | |||
Cerebellum | Arbor Vita of Cerebellum | 9.6 ± 0.3 | 9.7 ± 0.3 | 1.1 | 0.81 | |
Cerebellar Cortex | 47.8 ± 1.4 | 48.5 ± 1.3 | 1.5 | 0.70 | ||
Cerebellar Peduncle: Inferior | 1.0 ± 0.1 | 0.9 ± 0.1 | −11.9 | 0.15 | ||
Cerebellar Peduncle: Middle | 1.5 ± 0.1 | 1.4 ± 0.0 | −5.3 | 0.22 | ||
Cerebellar Peduncle: Superior | 0.9 ± 0.1 | 0.9 ± 0.1 | −0.1 | 0.99 | ||
60.8 ± 1.6 | 61.4 ± 1.6 | 1.1 | 0.78 | |||
Ventricles | Lateral Ventricle | 4.5 ± 0.2 | 4.0 ± 0.2 | −12.2 | 0.04 | |
Third Ventricle | 1.6 ± 0.1 | 1.5 ± 0.0 | −6.3 | 0.24 | ||
Cerebral Aqueduct | 0.7 ± 0.2 | 0.6 ± 0.1 | −17.7 | 0.43 | ||
Fourth Ventricle | 0.4 ± 0.1 | 0.3 ± 0.1 | −7.1 | 0.74 | ||
7.2 ± 0.3 | 6.4 ± 0.3 | −11.2 | 0.06 | |||
Brainstem | Colliculus: Inferior | 5.7 ± 0.2 | 5.8 ± 0.3 | 2.1 | 0.72 | |
Colliculus: Superior | 9.3 ± 0.5 | 9.3 ± 0.6 | 0.8 | 0.93 | ||
Corticospinal Tract | 2.3 ± 0.2 | 3.3 ± 0.6 | 41.9 | 0.14 | ||
Cuneate Nucleus | 0.2 ± 0.0 | 0.2 ± 0.0 | 1.0 | 0.94 | ||
Facial Nerve | 0.4 ± 0.1 | 0.3 ± 0.1 | −17.2 | 0.50 | ||
Inferior Olivary Complex | 0.6 ± 0.1 | 0.7 ± 0.1 | 7.5 | 0.57 | ||
Medial Lemniscus/Medial Longitudinal Fasciculus | 2.5 ± 0.2 | 2.5 ± 0.1 | 1.3 | 0.87 | ||
Pontine Nucleus | 0.9 ± 0.0 | 0.9 ± 0.0 | −0.5 | 0.91 | ||
Superior Olivary Complex | 0.8 ± 0.0 | 0.8 ± 0.0 | −8.7 | 0.18 | ||
Periaqueductal Grey | 4.2 ± 0.2 | 4.2 ± 0.2 | −0.7 | 0.93 | ||
Medulla | 25.5 ± 2.5 | 23.4 ± 1.7 | −8.2 | 0.49 | ||
Midbrain | 14.0 ± 0.4 | 13.8 ± 0.6 | −1.4 | 0.78 | ||
Pons | 16.8 ± 0.7 | 16.2 ± 0.7 | −3.6 | 0.55 | ||
Interpedunclar Nucleus | 0.3 ± 0.0 | 0.3 ± 0.0 | −2.1 | 0.76 | ||
Ventral Tegmental Decussation | 0.1 ± 0.0 | 0.1 ± 0.0 | −1.6 | 0.83 | ||
83.4 ± 2.7 | 81.6 ± 2.2 | −2.2 | 0.60 | |||
Total Brain volume | 464.0 ± 9.6 | 450.4 ± 10.00 | −2.9 | 0.80 | ||
