Figure 1
From: Properties of cell signaling pathways and gene expression systems operating far from steady-state
Characterization of a prototypical shifter: a ligand-receptor reaction. (A) Ligand-Receptor scheme, ligand binds free receptor reversibly with rate constants kon and koff. (B) Output (C, ligand-receptor complex) vs. time, for different values of input (color-coded using a heat-map scale). Circles over the curves mark output at time τ (time at which output is 63.2% of its steady-state value). (C) Input-output curves obtained at different times (color-coded using a heat-map scale). Circles mark the EC50. (D) τ vs. input. (E) EC50 (red) and nH (green) vs. time.
