Figure 1 | Scientific Reports

Figure 1

From: Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis

Figure 1

Effects of intra-articular administration of BMS-345541 in surgically-induced mouse knee osteoarthritis (OA). (a) Schematic representation of the surgical procedure for OA induction, intra-articular injections, and time of sacrifice. Injections were performed three times a week after surgery for 8 weeks. (b) Quantification of OA development using the Osteoarthritis Research Society International (OARSI) score for the first experiment. Symbols represent individual mice; long and short bars show the mean and SD, respectively. *P < 0.05, **P < 0.005 vs vehicle by ANOVA followed by Dunnett’s post hoc test. (c) Representative safranin O staining from each experimental group. Scale bar, 100 µm.

Back to article page