Figure 2 | Scientific Reports

Figure 2

From: Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis

Figure 2

Suppression of the NF-κB–Hif-2α pathway by BMS-345541 treatment. (a) Quantification of OA development using the Osteoarthritis Research Society International (OARSI) score from the follow-up experiment as a confirmatory phase. Symbols represent individual mice; long and short bars show the mean and SD, respectively. *P < 0.005 vs vehicle by ANOVA followed by Dunnett’s post hoc test. (b) Safranin O staining and immunohistochemistry of NF-κB-related proteins and catabolic enzymes in the BMS-345541-treated cartilage at 8 weeks after surgical induction of OA. Inset boxes in safranin O staining indicate enlarged images. Scale bar, 50 µm. (c) The percentage of positive cells according to immunohistochemistry. *P < 0.05 vs vehicle by the Kruskal–Wallis test and Dunn’s post hoc test for unequal variance.

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