Figure 5 | Scientific Reports

Figure 5

From: Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes

Figure 5

Liposomal trimer delivery maximizes humoral responses during primary immunization but less critical druing booster immunizations. Balb/c mice were immunized with 1 µg MD39 trimer and 0.2U ISCOMATRIX, and boosted at 6 weeks with the same formulations. (A) Serum MD39-6xhis-specific IgG titers (n = 3–4 animals/group); dotted line denotes limit of detection. (B) Avidity of polyclonal antibodies. Avidity was analyzed using independent unpaired t tests for direct comparisons; *p < 0.05.

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