Figure 5 | Scientific Reports

Figure 5

From: Whole-exome sequencing identifies two novel mutations in KCNQ4 in individuals with nonsyndromic hearing loss

Figure 5The alternative text for this image may have been generated using AI.

Potassium conductance of KCNQ4 channels assembled from tandem concatemers. (a) Representative K+ current traces recorded from the KCNQ4 channels assembled from WT-WT, WT-p.D266Y, and WT-p.V87_N89del concatemers. GFP-transfected cells were used as controls, and linopirdine-sensitive currents were subtracted for comparison. (b) Comparison of current densities at +40 mV. Means ± SEMs; WT-WT, n = 13; WT-p.D266Y, n = 12; WT-p.V87_N89del, n = 11; GFP, n = 6. NS, not significant; ***p < 0.005 versus WT-WT; #p < 0.05 versus WT-D266Y.

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