Figure 3 | Scientific Reports

Figure 3

From: The prebiotic inulin modulates gut microbiota but does not ameliorate atherosclerosis in hypercholesterolemic APOE*3-Leiden.CETP mice

Figure 3

Inulin adversely affected the liver by manifestations of hepatic inflammation Mice were fed a WTD containing 0.5% cholesterol ± inulin for 11 weeks. (A) Liver weight, (B) liver morphology, (C) hepatocyte size as a marker for hepatic hypertrophy, (D) microvesicular and macrovesicular steatosis, (E) liver TG content, (F) qRT-PCR analysis of F4/80, Mcp-1, Tnf-α, IL-6, IL-10, and (G) immunohistochemical analysis of hepatic F4/80 were determined. Values are presented as means ± SEM (n = 10 mice per group). *P < 0.05, **P < 0.01, ***P < 0.001 vs. control.

Back to article page