Figure 3
Ad-SF40L induces high levels of neutralizing antibodies. (A) F-specific total IgG in serum of primed/boosted mice 4 days post-challenge determined using ELISA (n = 5). The * in the legend indicates a significant difference in F-specific total IgG between Ad-SF40L and RSV at dilutions 1/1000, 1/2000 and 1/4000. (B) F-specific IgG1/IgG2a ratio in mice serum to show the Th2 or Th1 nature of the immune response (n = 5). (C) RSV neutralizing ability of the mice serum collected 4 days post-challenge (n = 8). Data shown is mean ± SEM representative of 2 independent experiments; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 (two-way ANOVA with Bonferroni posttest).
