Table 3 Results of orthogonal partial least squares discriminant analysis based on 7 potential biomarkers.

From: Biomarker Phenotype for Early Diagnosis and Triage of Sepsis to the Pediatric Intensive Care Unit

PICU-sepsis versus PED-sepsis

R2Y

Q2

CV-ANOVA p-value

Sensitivity: Specificity

PPV:NPV

Accuracy

AUROC ± standard error

1–23 month old cohort

0.46

0.44

1.8 × 10−13

0.80:0.88

0.84:0.85

0.85

0.90 ± 0.03

2–17 year old cohort

0.60

0.58

2.7 × 10−33

0.87:0.93

0.93:0.86

0.90

0.95 ± 0.02

1 month-17 year old cohort

0.53

0.52

2.3 × 10−22

0.84:0.89

0.89:0.84

0.86

0.93 ± 0.02

  1. AUROC: area under the receiver operating characteristic curve; PICU: pediatric intensive care unit; PED: emergency department; R2Y: percentage of variation explained by the model; Q2: predictive ability of the model; CV-ANOVA: cross-validated analysis of variance; PPV:NPV: positive predictive value: negative predictive value.
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