Table 1 EC501, CC502, and TI3 of CNSL-derived phenolic lipids.

From: Cardol triene inhibits dengue infectivity by targeting kl loops and preventing envelope fusion

Compounds

EC50 (µM)**

CC50 (μM)**

TI

Anacardic acid mixture

4.82 ± 1.71

58.80 ± 2.91

12.19

Anacardic acid saturated

4.31 ± 1.17

66.33 ± 1.58

15.39

Anacardic acid monoene

12.59 ± 0.84

74.00 ± 0.85

5.88

Anacardic acid diene

Not inhibited

112.17 ± 8.57

—

Anacardic acid triene

7.48 ± 2.14

115.13 ± 14.12

15.38

Cardanol mixture

11.06 ± 0.40

46.86 ± 2.94

4.23

Cardanol saturated

5.89 ± 2.83

43.51 ± 1.10

7.39

Cardanol monoene

7.65 ± 2.58

98.70 ± 3.16

12.90

Cardanol diene

Not inhibited

159.40 ± 7.41

—

Cardanol triene*

—

—

—

Cardol mixture

3.24 ± 0.51

60.51 ± 4.94

18.67

Cardol saturated

12.72 ± 0.67

58.75 ± 0.43°

4.62

Cardol diene

11.90 ± 0.82

71.66 ± 5.27°

6.02

Cardol triene

7.13 ± 0.72

207.30 ± 5.24

29.07

  1. 1Effective concentration of indicated phenolic lipid to DENV2 NGC (M.O.I. of 0.1) infected Vero cells.
  2. 2Cytotoxic concentration of indicated phenolic lipid to Vero cells.
  3. 3Therapeutic index (TI, CC50/EC50).
  4. *Insoluble.
  5. **Data represented means ± standard error of the means (SEM) from three independent experiments, unless otherwise indicated.
  6. °Data represented means ± standard error of the means (SEM) from two independent experiments due to limited compound availability.
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