Figure 8 | Scientific Reports

Figure 8

From: AP endonuclease EXO-3 deficiency causes developmental delay and abnormal vulval organogenesis, Pvl, through DNA glycosylase-initiated checkpoint activation in Caenorhabditis elegans

Figure 8

A model for the mechanisms of developmental delay and the increase in Pvl in the exo-3 mutant worms. Cleavage products produced by either NTH-1 or UNG-1 can cause checkpoint activation, leading to developmental delay when worms lack EXO-3, but not when worms lack APN-1. Moreover, UNG-1-inducing checkpoint activation results in an increase in dut-1 (RNAi)-induced Pvl when worms lack EXO-3, but not when they lack APN-1.

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