Figure 4

Kaplan-Meier survival analyses based on Shannon index for c-MYC copy number variation before and after neoadjuvant chemotherapy in subgroups according to hormone receptor status. In hormone receptor-positive subgroup, high Shannon indices before (A) and after (B) neoadjuvant chemotherapy (NAC) are associated with poor disease-free survival. On the contrary, in hormone receptor-negative subgroup, Shannon indices before (C) and after (D) NAC do not show association with patient survival.