Figure 1 | Scientific Reports

Figure 1

From: Pseudomonas aeruginosa mutants defective in glucose uptake have pleiotropic phenotype and altered virulence in non-mammal infection models

Figure 1

Glucose uptake pathways and organization of glucose uptake genes on P. aeruginosa genome. (a) Different porins allow glucose (empty square) entry into the periplasm. Once in the periplasm, glucose can be transported into the cytoplasm by Glt or oxidized to gluconate (grey square) and 2-KG (black square). Gluconate and 2-KG enter the cytoplasm thanks to GntP and KguT. Cylinders, outer membrane (OM) porins implicated in glucose uptake; ovals, inner membrane (IM) transporters. (b) Organization and regulation of glucose uptake genes in P. aeruginosa PAO1. 10 kbp long genomic regions encompassing the deleted loci encoding IM and OM proteins (represented as empty and dark boxes, respectively) are schematized. Boxes, ORFs; lines, intergenic regions; arrows on top of boxes indicate the transcription direction. Dashed lines connect genes encoding negative regulators with their target promoter(s).

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