Figure 6
From: A Rabbit Corneal Endothelial Dysfunction Model Using Endothelial-Mesenchymal Transformed Cells
Functional assessment after penetrating keratoplasty (PKP) performed 7 days after EMT-RCECs injection (A) Corneal thickness after penetrating keratoplasty performed 7 days after EMT-RCECs injection significantly decreased due to recovered pump function. Corneal thickness 28 days after PKP in EMT-RCECs rabbits was significantly less than untreated EMT-RCECs animals (p = 1.6 × 10−4) (***p < 0.001). (B) Anterior segment photographs of rabbit corneas 7 days after RCECs transplantation, and 1, 7, 21, 28 days after penetrating keratoplasty. Eyes transplanted with EMT-RCECs showed severe edema (upper panel), while eyes after penetrating keratoplasty (PKP) recovered transparency from the day after surgery (lower panel). (C) IOP was similar in both groups indicating that the difference in corneal thickness was not due to difference in IOP. (EMT-RCECs: black circles n = 3), (PKP group: gray squares n = 3), *p < 0.05, **p < 0.01, ***p < 0.001, Student’s t test. IOP: intraocular pressure, NS: not significant.
