Table 3 Seventy-three genes that were significantly down-regulated after 6-week HIIT.

From: Gene expression profile of muscle adaptation to high-intensity intermittent exercise training in young men

Gene symbol

Gene description

Expression value

Fold change

P-value

Before

After

AASS

aminoadipate-semialdehyde synthase

167.2

128.6

0.77

0.00022

ADHFE1

alcohol dehydrogenase, iron containing, 1

382.8

305.8

0.80

0.00018

ALDH2

aldehyde dehydrogenase 2 family (mitochondrial)

249.8

178.3

0.71

2.27E-06

ALDH6A1

aldehyde dehydrogenase 6 family, member A1

130.0

103.2

0.79

0.00027

ASB15

ankyrin repeat and SOCS box containing 15

542.1

378.8

0.70

9.14E-07

B3GALT1

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1

120.3

80.9

0.67

9.89E-05

C3orf26

chromosome 3 open reading frame 26

70.7

54.3

0.77

0.00012

C8orf22

chromosome 8 open reading frame 22

2864.8

2091.7

0.73

0.00074

CADM2

cell adhesion molecule 2

54.7

42.8

0.78

3.48E-04

CCDC141

coiled-coil domain containing 141

45.9

36.3

0.79

0.00184

CD38

CD38 molecule

287.3

224.0

0.78

0.00139

DHCR24

24-dehydrocholesterol reductase

112.4

83.6

0.74

7.05E-06

DMGDH

dimethylglycine dehydrogenase

56.2

43.8

0.78

0.00041

EFR3A

EFR3 homolog A (S. cerevisiae)

458.1

364.8

0.80

1.13E-04

EGFR

epidermal growth factor receptor

128.2

101.5

0.79

7.09E-05

EPB41

erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)

183.4

144.8

0.79

0.00058

EYA1

eyes absent homolog 1 (Drosophila)

143.1

111.0

0.78

1.62E-05

FAM126A

family with sequence similarity 126, member A

162.7

114.5

0.70

1.01E-03

FBXO48

F-box protein 48

80.1

60.8

0.76

0.00267

FLJ43663

uncharacterized LOC378805

149.3

102.7

0.69

2.56E-04

GATSL1

GATS protein-like 1

423.2

336.8

0.80

0.00011

GPT2

glutamic pyruvate transaminase (alanine aminotransferase) 2

143.9

106.6

0.74

0.00017

HIST2H2AC

histone cluster 2, H2ac

1263.4

957.1

0.76

0.00175

HN1

hematological and neurological expressed 1

61.1

48.3

0.79

4.14E-05

HSPB1

heat shock 27 kDa protein 1

1910.4

1494.8

0.78

8.53E-05

HSPB3

heat shock 27 kDa protein 3

271.0

211.9

0.78

0.00019

IFIT1

interferon-induced protein with tetratricopeptide repeats 1

56.0

41.0

0.73

0.00012

IL17D

interleukin 17D

119.3

94.1

0.79

0.00030

IL32

interleukin 32

82.0

55.0

0.67

5.80E-05

KIF1B

kinesin family member 1B

437.7

343.4

0.78

0.00028

LGI1

leucine-rich, glioma inactivated 1

77.2

57.5

0.75

0.00036

LGR5

leucine-rich repeat containing G protein-coupled receptor 5

360.0

214.3

0.60

0.00083

LMOD1

leiomodin 1 (smooth muscle)

76.3

58.9

0.77

4.23E-05

LOC100128560

uncharacterized LOC100128560

56.2

37.5

0.67

0.00207

LOC100188947

uncharacterized LOC100188947

67.1

45.2

0.67

0.00103

LOC100505769

uncharacterized LOC100505769

100.8

78.9

0.78

0.00242

LOC100506338

uncharacterized LOC100506338

75.9

60.0

0.79

1.10E-04

LOC646903

uncharacterized LOC646903

172.2

123.4

0.72

0.00016

MFAP4

microfibrillar-associated protein 4

209.4

152.8

0.73

0.00167

MIR4681

microRNA 4681

65.3

51.6

0.79

4.59E-05

MKNK2

MAP kinase interacting serine/threonine kinase 2

287.6

221.2

0.77

0.00017

MSTN

myostatin

139.8

73.6

0.53

6.92E-06

MT1X

metallothionein 1×

1524.8

1169.2

0.77

0.00108

MYH1

myosin, heavy chain 1, skeletal muscle, adult

4283.1

2788.7

0.65

0.00233

MYLK2

myosin light chain kinase 2

701.4

534.4

0.76

0.00148

MYOM3

myomesin family, member 3

282.3

190.2

0.67

5.58E-05

NEK10

NIMA (never in mitosis gene a)- related kinase 10

145.5

108.4

0.74

9.22E-05

NRAP

nebulin-related anchoring protein

4720.4

3508.3

0.74

1.91E-06

NT5C2

5′-nucleotidase, cytosolic II

413.8

311.6

0.75

0.00077

NUP160

nucleoporin 160 kDa

84.1

66.5

0.79

5.87E-04

OXCT1

3-oxoacid CoA transferase 1

115.0

79.9

0.70

0.00101

PAIP2B

poly(A) binding protein interacting protein 2B

517.1

382.1

0.74

0.00039

PDLIM3

PDZ and LIM domain 3

2003.3

1553.8

0.78

0.00012

PFN2

profilin 2

243.7

189.8

0.78

9.41E-05

POLR2J

polymerase (RNA) II (DNA directed) polypeptide J, 13.3 kDa

109.9

78.1

0.71

0.00026

PRKAG3

protein kinase, AMP-activated, gamma 3 non-catalytic subunit

194.4

145.4

0.75

0.00035

PYGO1

pygopus homolog 1 (Drosophila)

129.5

100.3

0.77

0.00051

SF3A1

splicing factor 3a, subunit 1, 120 kDa

129.0

103.0

0.80

1.08E-04

SH3RF2

SH3 domain containing ring finger 2

104.6

75.9

0.73

6.20E-05

SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

61.7

49.3

0.80

0.00142

SLC25A33

solute carrier family 25 (pyrimidine nucleotide carrier), member 33

147.8

113.2

0.77

0.00201

SLITRK4

SLIT and NTRK-like family, member 4

70.5

52.8

0.75

0.00243

SMTNL1

smoothelin-like 1

318.2

184.2

0.58

4.52E-04

TMEM47

transmembrane protein 47

544.1

433.1

0.80

0.00039

TP63

tumor protein p63

136.6

90.8

0.67

8.80E-04

TSC22D1

TSC22 domain family, member 1

185.1

142.2

0.77

0.00034

UNC13B

unc-13 homolog B (C. elegans)

194.8

155.9

0.80

0.00036

UNC13C

unc-13 homolog C (C. elegans)

61.8

48.2

0.78

0.00132

WBP11

WW domain binding protein 11

94.3

74.5

0.79

0.00121

WDR5B

WD repeat domain 5B

50.8

40.6

0.80

0.00092

YIPF7

Yip1 domain family, member 7

295.9

235.9

0.80

0.00055

ZFP36

zinc finger protein 36, C3H type, homolog (mouse)

118.9

94.1

0.79

0.00023

ZNF844

zinc finger protein 844

65.9

51.8

0.79

0.00065

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