Figure 6
Heatmaps of a selected panel of immunity-related genes expressed in proximal colon (A) and ileum (B). Genes differentially expressed in old (O) versus young (Y) mice which are upregulated are shown in red and genes that are down-regulated are shown in blue. Scale: Log2(Fold Change) = −1 (blue) <0 (white) <1 (red). Genes in white are not differentially expressed between old and young mice and have fold changes between −1 and +1. The intensity of the red and blue colours is proportional to change in expression. Ighv and Igkv gene annotations are variable regions of the kappa and heavy immunoglobulin chains; differences in expression of these genes is interpreted as indicating altered antibody expression by plasma cells in the mucosa of old vs young mice.
