Table 2 Over-represented pathways relevant to BPD pathogenesis.

From: Gene Expression Signatures Point to a Male Sex-Specific Lung Mesenchymal Cell PDGF Receptor Signaling Defect in Infants Developing Bronchopulmonary Dysplasia

Pathway name

p-value

q-value

Genes

Extracellular matrix organization

1.00E-05

0.00149

ITGA8, ADAMTS5, BMP4, ADAMTS1, COL4A5, FBN2, ADAMTS8, NID1, LTBP4, COL21A1, FBLN1, MMP3

Elastic fiber formation

1.25E-05

0.001485

ITGA8; BMP4; FBLN1; LTBP4; FBN2

Degradation of the extracellular matrix

0.00248

0.042772

ADAMTS5; NID1; ADAMTS1; ADAMTS8; MMP3

Signaling by PDGF

0.008485

0.049294

PDGFRA; TEK; PDGFD; COL4A5; GFRA1; FGF9; FGF7; KITLG

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