Table 2 Inhibition of basal levels of key osteoarthritis matrix metalloproteinase mRNA expression in primary chondrocytes.
From: Identifying chondroprotective diet-derived bioactives and investigating their synergism
Basal | MMP1 | MMP13 | ADAMTS4 | ADAMTS5 | ||||
|---|---|---|---|---|---|---|---|---|
Bioactive | Mean FC (95% CI) | p-value | Mean FC (95% CI) | p-value | Mean FC (95% CI) | p-value | Mean FC (95% CI) | p-value |
Genistin | 1.03 (−2.55 to 2.50) | 0.999 | 1.09 (−3.14 to 2.96) | 0.999 | — | — | 0.96 (−0.48 to 0.56) | 0.999 |
Luteolin | 0.96 (−2.48 to 2.56) | 0.999 | 1.83 (−3.88 to 2.22) | 0.997 | — | — | 0.71 (−0.23 to 0.81) | 0.766 |
Polydatin | 0.90 (−2.42 to 2.62) | 0.999 | 1.88 (−3.93 to 2.16) | 0.985 | — | — | 0.98 (−0.50 to 0.54) | 0.999 |
Curcumin | 1.13 (−2.65 to 2.39) | 0.999 | 2.43 (−4.48 to 1.61) | 0.822 | — | — | 0.70 (−0.22 to 0.83) | 0.838 |
Apigenin | 0.76 (−2.28 to 2.77) | 0.912 | 2.05 (−4.10 to 2.00) | 0.996 | — | — | 0.59 (−0.11 to 0.93) | 0.337 |
Myricetin | 0.74 (−2.26 to 2.78) | 0.914 | 1.89 (−3.94 to 2.16) | 0.999 | — | — | 0.77 (−0.29 to 0.75) | 0.965 |
Isoliqu | 0.95 (−2.47 to 2.57) | 0.999 | 2.02 (−4.07 to 2.02) | 0.991 | — | — | 0.49 (−0.03 to 1.01) | 0.148 |
Ursolic acid | 4.35 (−5.87 to −0.82) | 0.004 | 0.64 (−3.04 to 3.77) | 0.864 | — | — | 0.69 (−0.21 to 0.83) | 0.532 |
EGCG | 1.11 (−2.63 to 2.41) | 0.999 | 1.81 (−3.86 to 2.24) | 0.999 | — | — | 0.62 (−0.14 to 0.90) | 0.442 |
Naringin | 0.95 (−2.48 to 2.57) | 0.999 | 1.09 (−3.14 to 2.95) | 0.999 | — | — | 0.92 (−0.44 to 0.60) | 0.999 |
Sulforaphane | 0.92 (−2.44 to 2.60) | 0.999 | 1.75 (−3.80 to 2.29) | 0.993 | — | — | 0.25 (0.23 to 1.27) | 0.001 |
