Figure 4
Inhibition of STAT3 reduces AR activity in PSAhi ENZR cells in vivo. (A) Weekly mean tumour volume (Left) and serum prostate-specific antigen (PSA) levels (Right) in mice treated with GPA500 5 mg/kg/day versus vehicle. Treatment was started when tumours reached 200 mm3 and was given intraperitoneally for 5 days on and 2 days off. (B) Protein expression of PSA, CyclinD1 and Vinculin in collected tumors treated with vehicle (control M1, M2 and M3) or GPA500 5 mg/kg (M4, M5 and M6).
