Figure 4
Representative hematoxylin-eosin-stained sections of FUS focus area and records of plasma fibrinogen level. (A) The samples were collected after 2 FUS-BBB openings on Days 1 and 3 and the animals were sacrificed on Day 8. Significant tissue damage was noted in the treated side in the 1.4-MI exposure group. n = 10. Scale bar: 50 µm, White arrow: fibrin deposition/hematoma, Black arrowhead: hemosiderin deposition, Black arrow: spotty necrosis. (B) Comparison of plasma fibrinogen concentration between 4 groups (mg/dL) collected on Day 8. Compared to the untreated group (Control), rats that received 2 1.4-MI exposures had significantly higher plasma fibrinogen levels compared to other groups; n = 10, *p < 0.05.
