Figure 5 | Scientific Reports

Figure 5

From: Safety evaluation of frequent application of microbubble-enhanced focused ultrasound blood-brain-barrier opening

Figure 5

Representative TUNEL assay of the FUS focus area in the standard microbubble dose group. Rats were treated with one or two instances of either 0.8- or 1.4-MI FUS-BBB opening. All were given 0.15 ml/kg of microbubbles prior to FUS application. Positive TUNEL assay is represented by co-localization of blue and green fluorescence in the nucleus, while green fluorescence in the cytoplasm is viewed as artifact. Cellular apoptosis was not detected in either the 0.8- or the 1.4-MI exposure groups. n = 6. Scale bar: 20 µm, Blue: DAPI. Green: TUNEL assay. Arrow: positive TUNEL assay. Arrowhead: artifact.

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