Table 2 Summary of the experimental parameters.

From: Safety evaluation of frequent application of microbubble-enhanced focused ultrasound blood-brain-barrier opening

Group

Protocol

FUS strength

Exposure level (MI)

Dose volume of microbubble solution (mL/kg)

Exposure Frequency

Animal number

5

I

Moderate

0.8

0.15

Day 1

6

6

I

Moderate

0.8

0.15

Day 1, 3

6

7

I

Heavy

1.4

0.15

Day 1

6

8

I

Heavy

1.4

0.15

Day 1, 3

6

9

II

Moderate

0.33

0.4

Day 1

6

10

II

Moderate

0.33

0.4

Day 1, 3

6

11

II

Moderate

0.33

0.4

Day 1, 3, 5

6

12

II

Heavy

0.8

0.4

Day 1

6

13

II

Heavy

0.8

0.4

Day 1, 3

6

14

II

Heavy

0.8

0.4

Day 1, 3, 5

6

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