Table 1 The relationships between NKX6.3, p53, EP300 and AICDA protein expression and clinical pathological parameters in gastric cancer.
From: Multiple genetic mutations caused by NKX6.3 depletion contribute to gastric tumorigenesis
NKX6.3 | P value | p53 | P value | EP300 | P value | AICDA | P value | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
+ | − | + | − | + | − | + | − | |||||
Total | 33 | 118 | <0.0001 | 65 | 86 | 0.1036 | 60 | 91 | 0.0146 | 54 | 97 | 0.0006 |
Tumor volume | 0.9364 | 0.3856 | 0.5741 | 0.6175 | ||||||||
<6.5 | 18 | 63 | 38 | 43 | 30 | 51 | 27 | 54 | ||||
≥6.5 | 15 | 55 | 27 | 43 | 30 | 40 | 27 | 43 | ||||
Gender | 0.4212 | 0.599 | 0.392 | 0.3827 | ||||||||
Male | 25 | 73 | 40 | 58 | 41 | 57 | 38 | 60 | ||||
Female | 8 | 45 | 25 | 28 | 19 | 34 | 16 | 37 | ||||
Age | 0.9364 | 0.3856 | 0.5741 | 0.6175 | ||||||||
≤60 | 20 | 69 | 34 | 55 | 37 | 52 | 31 | 58 | ||||
>60 | 13 | 49 | 31 | 31 | 23 | 39 | 23 | 39 | ||||
Site | 0.4212 | 0.599 | 0.392 | 0.6237 | ||||||||
Upper | 5 | 10 | 5 | 10 | 8 | 7 | 4 | 11 | ||||
Lower | 28 | 108 | 60 | 76 | 52 | 84 | 50 | 86 | ||||
L/N metastasis | 0.8262 | 0.8059 | 0.7136 | 0.6033 | ||||||||
LN (+) | 32 | 116 | 63 | 85 | 59 | 89 | 52 | 96 | ||||
LN (−) | 1 | 2 | 2 | 1 | 1 | 2 | 2 | 1 | ||||
Tumor stage | 0.0026 | 0.2302 | 0.0553 | 0.039 | ||||||||
T1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
T2 | 18 | 28 | 18 | 28 | 24 | 22 | 10 | 36 | ||||
T3 | 15 | 87 | 47 | 55 | 36 | 66 | 42 | 60 | ||||
T4 | 0 | 3 | 0 | 3 | 0 | 3 | 2 | 1 | ||||
N stage | <0.0001 | 0.148 | 0.0889 | 0.4184 | ||||||||
N0 | 3 | 0 | 3 | 0 | 3 | 0 | 0 | 3 | ||||
N1 | 10 | 9 | 10 | 9 | 10 | 9 | 5 | 14 | ||||
N2 | 9 | 25 | 15 | 19 | 13 | 21 | 12 | 22 | ||||
N3 | 11 | 84 | 37 | 58 | 34 | 61 | 37 | 58 | ||||
TNM stage | <0.0001 | 0.1373 | 0.029 | 0.0539 | ||||||||
I | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | ||||
II | 17 | 9 | 15 | 11 | 16 | 10 | 5 | 21 | ||||
III | 15 | 107 | 49 | 73 | 43 | 79 | 47 | 75 | ||||
IV | 0 | 2 | 0 | 2 | 0 | 2 | 2 | 0 | ||||
Lauren’s | 0.3217 | 0.5166 | 0.324 | 0.3694 | ||||||||
intestinal | 11 | 53 | 30 | 34 | 22 | 42 | 26 | 38 | ||||
diffuse | 22 | 65 | 35 | 52 | 38 | 49 | 28 | 59 | ||||
p53 | 0.6066 | |||||||||||
+ | 16 | 49 | ||||||||||
− | 17 | 69 | ||||||||||
EP300 | <0.0001 | 0.8214 | ||||||||||
+ | 25 | 35 | 27 | 33 | ||||||||
− | 8 | 85 | 38 | 53 | ||||||||
AICDA | <0.0001 | 0.4394 | 0.0056 | |||||||||
+ | 0 | 54 | 26 | 28 | 13 | 41 | ||||||
− | 33 | 64 | 39 | 58 | 47 | 50 | ||||||