Figure 1
Crystal structure and NMR validation of the IgV domain of hTIM-3. (a) 15N-HSQC of 15N/13C labeled hTIM-3 acquired at 25 °C on an Agilent 700-MHz spectrometer, with amino acids assignments shown in red. (b) Ribbon diagram of the hTIM-3 IgV domain crystal structure with bound Ca++ in red. The β strands are labeled with uppercase letters and loops are highlighted in italics. (c) Surface view of Ca++ bound hTIM-3. The β strands and loops are labeled as above.
