Figure 7
Comparison of potential glycosylation sites of hTIM-3 and mTIM-3. (a) Potential N- and O-glycans sites of mTIM-3 mapped at residues Thr44, Asn74, and Asn100. mTIM-3 crystal structure (PDB code 2OYP) is shown in red ribbon representation and potential glycosylation sites are highlighted in blue stick representation. (b) Potential N- and O-glycans sites of hTIM-3 mapped at residues Asn33, Asn100, and Asn124. hTIM-3 crystal structure is shown in green ribbon representation with bound Ca++ and potential glycosylation sites are highlighted in blue stick representation. (c) Surface view of mTIM-3 glycan sites in blue. The mTIM-3 molecule is rotated ~180° about a vertical axis when compared to mTIM-3 molecule as shown in (a). (d) Surface view of hTIM-3 glycan sites in blue. The hTIM-3 molecule is rotated ~180° about a vertical axis when compared to hTIM-3 molecule as shown in (b).
