Figure 1
Identification of an ESC miRNA signature score that stratifies neuroblastoma patients within a subset of high-stage neuroblastoma. (A) ESC miRNA signature scores in embryonic stem cells (ESC line)25, neuroblastoma tumors (NB tumors)26 and normal neuroblasts4 (the error bars represent standard deviations, p-values from Mann-Whitney tests). (B) ESC miRNA signature scores in MYCN non amplified neuroblastoma tumors (MNA) compared to MYCN amplified neuroblastoma tumors (MA) (p-value from t-test). (C,D) Kaplan-Meier and log rank analysis of 200 neuroblastoma patients with a high or low ESC miRNA signature score (using median as cut-off). DOD, dead of disease. (E,F) Kaplan-Meier and log rank analysis within the subset of stage 4 MYCN non amplified patients. (G) ESC miRNA A signature score during tumor development in Th-MYCN transgenic mice. (H) ESC miRNA signature scores for MYCN, ALKF1174L and Lin28b neuroblastoma mice tumors and their normal counterparts (adrenal gland and brain tissue) (p-value from Mann-Whitney test).
