Table 3 Functional annotation clustering according to DAVID Functional Annotation Clustering Tool integrated in DAVID Bioinformatics Resources.

From: Prenatal circulating microRNA signatures of foetal Down syndrome

Gene cluster 1

TIA1

TIA1 cytotoxic granule associated RNA binding protein

RBMS1

RNA binding motif single stranded interacting protein 1

IGF2BP3

Insulin like growth factor 2 mRNA binding protein

NCL

Nucleolin

HNRNPA0

Heterogenous nuclear ribonucleoprotein A0

RBM19

RNA binding motif protein 19

Gene cluster 2

MAP4K4

Mitogen-activated protein kinase 4

MAPKAPK2

Mitogen-activated protein kinase-activated protein kinase 2

WEE1

WEE1 G2 checkpoint kinase

BMP2K

BMP2 inducible kinase

HIPK3

Homeodomain interacting protein kinase

CHEK1

Checkpoint kinase 1

Gene cluster 3

KRT85

Keratin 85

KRT19

Keratin 19

LMNB1

Lamin B1

VIM

Vimentin

KRT7

Keratin 7

LMNB2

Lamin B2

Gene cluster 4

RAB21

Member RAS oncogene family

RHOG

Ras homolog family member

RAB9B

Member RAS oncogene family

RHOB

Ras homolog family member

RAB30

Member RAS oncogene family

RAB27B

Member RAS oncogene family

Gene cluster 5

CDCP1

CUB domain containing protein 1

SLC16A10

Solute carrier family 16 member 10

SLC7A11

Solute carrier family 7 member 11

SLC38A1

Solute carrier family 38 member 1

SLC7A1

Solute carrier family 7 member 1

SLC38A5

Solute carrier family 38 member 5

SLC38A2

Solute carrier family 38 member 2

Gene cluster 6

SLC25A1

Solute carrier family 25 member 1

SLC25A32

Solute carrier family 25 member 32

SLC25A24

Solute carrier family 25 member 24

UCP2

Uncoupling protein 2

SLC25A13

Solute carrier family 25 member 13

SLC25A22

Solute carrier family 25 member 22

Gene cluster 7

CLDN12

Claudin 12

TMEM251

Transmembrane protein 251

C2orf74

Chromosome 2 open reading frame 74

C17orf80

Chromosome 17 open reading frame 80

TVP23B

Trans-golgi network vesicle protein 23 homolog B

TMEM59

Transmembrane protein 59

RFT1

RFT1 homolog

CA12

Carbonic anhydrase 12

TMEM87A

Transmembrane protein 87A

TMEM106C

Transmembrane protein 106C

SLC8A5

Solute carrier family 8 member 5

TMEM41B

Transmembrane protein 41B

NIPAL2

NIPA like domain containing 2

FAM69A

Family with sequence similarity 69 member A

CDCP1

CUB domain containing

ACP2

Acid phosphatase 2, lysosomal

SLC35B3

Solute carrier family 35 member B3

PRRG4

Proline rich and Gla domain 4

YIF1B

Yip1 interacting factor homolog B, membrane trafficking protein