Table 1 Diagnostic performance of different test combinatons.

From: Increased Diagnostic Yield of Tuberculous Serositis by Using Serous Fluid Drainage Flocky Precipitate (SFDFP) as a Testing Sample

 

Valid %*

Sensitivity

(95% CI)

Specificity

(95% CI)

PPV

(95% CI)

NPV

(95% CI)

AUC*

Kappa*

P value*

Xpert/RIF on SF

97.6

0.28 (0.19–0.40)

1.00 (0.80–1.00)

1.00 (0.83–1.00)

0.23 (0.15–0.35)

0.650

0.11

0.008

Xpert/RIF on SFDFP

85.5

0.36 (0.25–0.48)

1.00 (0.78–1.00)

1.00 (0.85–1.00)

0.27 (0.17–0.40)

0.679

0.16

0.359

Smear on SF

100

0.07 (0.03–0.16)

1.00 (0.77–1.00)

1.00 (0.57–1.00)

0.27 (0.17–0.26)

0.536

0.02

0.000

Culture on SF

98.8

0.20 (0.12–0.31)

1.00 (0.76–1.00)

1.00 (0.78–1.00)

0.18 (0.10–0.28)

0.554

0.07

0.000

Smear on SFDFP

89.2

0.15 (0.08–0.25)

1.00 (0.76–1.00)

1.00 (0.70–1.00)

0.18 (0.11–0.30)

0.578

0.05

0.000

Culture on SFDFP

89.2

0.16 (0.09–0.27)

1.00 (0.76–1.00)

1.00 (0.72–1.00)

0.19 (0.11–0.30)

0.585

0.06

0.001

Pathology on SFDFP

86.7

0.19 (0.11–0.30)

1.00 (0.77–1.00)

1.00 (0.74–1.00)

0.21 (0.13–0.33)

0.657

0.08

0.001

S + C on SF

100

0.24 (0.16–0.35)

1.00 (0.77–1.00)

1.00 (0.82–1.00)

0.20 (0.12–0.31)

0.621

0.09

0.002

S + C on SFDFP

89.2

0.16 (0.09–0.27)

1.00 (0.76–1.00)

1.00 (0.72–1.00)

0.19 (0.11–0.30)

0.585

0.06

0.001

S + C + P on SFDFP

90.4

0.26 (0.17–0.38)

1.00 (0.77–1.00)

1.00 (0.81–1.00)

0.22 (0.13–0.34)

0.671

0.11

0.013

S + C + X on SF

100

0.41 (0.31–0.53)

1.00 (0.77–1.00)

1.00 (0.88–1.00)

0.24 (0.15–0.37)

0.707

0.18

—

S + C + P + X on SFDFP

91.6

0.48 (0.36–0.60)

1.00 (0.77–1.00)

1.00 (0.89–1.00)

0.28 (0.17–0.43)

0.764

0.24

1.000

All on SFDFP & SF

100

0.60 (0.48–0.71)

1.00 (0.77–1.00)

1.00 (0.92–1.00)

0.32 (0.20–0.47)

0.800

0.32

0.004

Elispot on PBMCs*

100

0.63 (0.51–0.73)

0.69 (0.42–0.87)

0.92 (0.80–0.97)

0.26 (0.14–0.42)

0.660

0.19

0.007

  1. Notes: Abbreviated Words: “S” means smear; “C” means culture; “P” means histopathologic examination; “X” means Xpert assay; “SF” means serious fluid; “SFDFP” means serous fluid drainage flocky precipitate.
  2. *“Valid” means the proportion of cases with available sample and results for all analyzed cases; “AUC” means the area under the receiver operating characteristic (ROC) curve. “Kappa” value was used to assess the agreement between the test (or test combination) and the composite reference standard (categorized as TB serositis or non-TB serositis). “p value” referred to the “S + C + X on SF” row, which stands for the routine decision-making tests to “confirm TB serositis”. The “p value” here was used to assess the statistical significance to our routine definitive methods. “Elispot on PBMC” means T-Spot test on blood samples.
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