Table 2 Effects of 6,7-dehydroroyleanone, horminone and 7-O-acetylhorminone on platelet aggregation (n = 7, \(\overline{x}\) ± s).

From: Antithrombotic effects and related mechanisms of Salvia deserta Schang root EtOAc extracts

 

Group

Concentration/µg/mL

MAR/%

MAIR/%

6,7-dehydroroyleanone

Aspirin

100

16.7 ± 4.31

62.3 ± 11.5

Control

97.1 ± 1.86Δ

High

1000

50.6 ± 10.20*Δ

47.8 ± 10.5Δ

Medium

100

73.0 ± 5.90*Δ

24.7 ± 6.07Δ

Low

10

94.4 ± 6.08Δ

1.20 ± 5.31Δ

p-value (Dose)

 

<0.0001

 

p-value (Aspirin + Dose)

 

<0.0001

<0.0001

Horminone

Aspirin

100

17.35 ± 4.63

61.70 ± 5.82

Control

91.00 ± 2.89Δ

High

1000

66.10 ± 4.80*Δ

27.50 ± 5.28Δ

Medium

100

79.10 ± 1.21*Δ

13.00 ± 1.36Δ

Low

10

85.80 ± 1.68*Δ

6.10 ± 2.13Δ

p-value (Dose)

 

<0.0001

 

p-value (Aspirin + Dose)

 

<0.0001

<0.0001

7-O-acetylhorminone

Aspirin

100

18.03 ± 5.06

58.63 ± 8.91

Control

65.1 ± 7.15Δ

High

1000

42.60 ± 7.02*Δ

34.50 ± 10.80Δ

Medium

100

51.80 ± 6.25*Δ

17.80 ± 4.70Δ

Low

10

63.40 ± 4.93Δ

2.40 ± 7.60Δ

p-value (Dose)

 

<0.0001

 

p-value (Aspirin + Dose)

 

<0.0001

<0.0001

  1. *P < 0.05 significant difference compared to control group; ΔP < 0.05 significant difference compared to aspirin group.
  2. MAIR (%) = platelet aggregation rate of the control group% - platelet aggregation rate of test drug treated group% / platelet aggregation rate of the control group%.