Figure 4 | Scientific Reports

Figure 4

From: Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet

Figure 4

High-fat diet fed female Ad-B2(−/−) mice resist weight gain at thermoneutrality. Body weight progression (A) and percentage of body weight gain (B) in twenty-four week old B2(fl/fl), Ad-B2(+/−) and Ad-B2(−/−) female mice housed at thermoneutrality and fed a high-fat diet for four weeks (n = 5–6). Relative GWAT mRNA levels (C) and circulating serum levels of adiponectin (D) and leptin (E) in twenty-eight week old B2(fl/fl), Ad-B2(+/−) and Ad-B2(−/−) mice fasted for 5 hours (n = 5–6). mRNA levels of white and brown markers in (F) BAT (n = 4–6) and (G) GWAT (n = 5–6) in twenty-eight week old B2(fl/fl), Ad-B2(+/−) and Ad-B2(−/−) mice. All data are presented as the mean ± SEM, *p < 0.05 vs B2(fl/fl), #p < 0.05 vs Ad-B2(+/−).

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