Figure 7 | Scientific Reports

Figure 7

From: Effective nose-to-brain delivery of exendin-4 via coadministration with cell-penetrating peptides for improving progressive cognitive dysfunction

Figure 7

Immunohistological staining of brain specimens with anti-NeuN antibody after long-term (30 times) intranasal administrations to SAMR1 control and SAMP8 with progressive cognitive dysfunction. (A–E) Microscopic observations of hippocampal areas of SAMP8 administered PBS (N = 5), exendin-4 only (N = 4), exendin-4 with L-penetratin (N = 7), or exendin-4 with L-penetratin plus insulin (N = 5) and SAMR1 administered PBS (N = 8), respectively. Panel F quantitative analysis of the NeuN-positive cells calculated from each image. CA, cornu ammonis, DG, dentate gyrus. Tests were conducted at 38 weeks of age. Each data point represents the mean ± SEM of n = 4–8.

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