Figure 8 | Scientific Reports

Figure 8

From: Effective nose-to-brain delivery of exendin-4 via coadministration with cell-penetrating peptides for improving progressive cognitive dysfunction

Figure 8

Immunological staining of the brain specimens with anti-human Aβ (1–42) antibody after the long-term (30 times) intranasal administration to SAMR1 control and SAMP8 with progressive cognitive dysfunction. (A–C) Microscopic observations of hippocampal areas of SAMR1 administered PBS (N = 8) and those of SAMP8 administered PBS (N = 5) or exendin-4 with L-penetratin plus insulin (N = 5). (D–F) Enlarged images of the areas indicated in panels A–C, respectively. CA, cornu ammonis, DG, dentate gyrus. Tests were conducted at 38 weeks of age.

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