Table 3 Glibenclamide metabolic kinetic parameters in human recombinase CYP2C9*1/*2/*3 (n = 3, mean ± SD).

From: OATP1B3 (699G>A) and CYP2C9*2, *3 significantly influenced the transport and metabolism of glibenclamide and glipizide

Protein

Km (μmol/L)

Vmax (nmol/min/mg)

CLint

CYP2C9*1

3.17 ± 1.02

1.58 ± 0.71

0.45 ± 0.12

CYP2C9*2

3.46 ± 1.56

0.69 ± 0.25**

0.20 ± 0.17**

CYP2C9*3

3.90 ± 2.34*

0.41 ± 0.13**

0.12 ± 0.08**

  1. **p < 0.01, *p < 0.05 (vs CYP2C9*1 group), CLint (intrinsic clearance) = Vmax/Km.
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