Table 4 Glipizide metabolic kinetic parameters in human recombinase CYP2C9*1/*2/*3 (n = 3, mean ± SD).

From: OATP1B3 (699G>A) and CYP2C9*2, *3 significantly influenced the transport and metabolism of glibenclamide and glipizide

Protein

Km (μmol/L)

Vmax (nmol/min/mg)

CLint

CYP2C9*1

3.07 ± 1.31

8.82 ± 2.78

2.95 ± 1.61

CYP2C9*2

3.51 ± 1.76

5.99 ± 1.95*

1.69 ± 0.47*

CYP2C9*3

4.10 ± 2.66*

2.87 ± 1.03**

0.72 ± 0.48**

  1. **p < 0.01, *p < 0.05 (vs CYP2C9*1 group), CLint (intrinsic clearance) = Vmax/Km.
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